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While initial studies indicate it may offer superior weight loss benefits, the long-term safety data are still developing

Although the number of beige adipocytes did not increase, they displayed a more thermogenic phenotype characterized by smaller LDs, elevated expression of uncoupling protein 1 ( UCP1 ) and HSL , and enhanced glucose utilization, all features consistent with increased mitochondrial uncoupling and browning

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The exact cellular localization of the GLP-1R remains equivocal due to the lack of selective antibodies and application of specific anti-GPCR antibodies (22)

2.1.2.5 Research funding - Allocate funding for comparative-effectiveness research on various treatment modalities for pediatric obesity, including assessments of GLP-1 RAs in relation to bariatric surgery