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If symptoms persist beyond the early titration period, temporary dose stabilization or dose reduction should be considered

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95% CI, 0.11-0.99)

After 56 weeks: Placebo group lost 1.6% of body weight Starting dose (3.75/23 mg) group lost 5.1% of body weight Top dose (15/92 mg) group lost 10.9% of body weight Beyond weight loss, the CONQUER trial showed significant improvements in blood pressure, waist circumference, lipid profiles, glycemic parameters, and inflammatory biomarkers compared to placebo

J Adv Res Discovery and identification of semaphorin 4D as a bioindicator of high fracture incidence in type 2 diabetic mice with glucose control