how does a glp 1 receptor agonist work Frontiers Glp 1 Agonists How They
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10.1016/S0140-6736(19)31150-X [DOI] [PubMed] [Google Scholar] 69
The most consistent lipid change observed with GLP-1 therapy is a reduction in triglycerides , typically ranging from 10-20% in clinical studies
doi: 10.1016/j.ejim.2017.07.020 12 DruckerD
In mice, liraglutide blunts hypertension induced by angiotensin II (Ang-II), an effect that is absent in GLP-1R KO mice, and is also attenuated upon pretreatment of WT mice with exendin (939) [640]
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In 2002, a 6-week subcutaneous infusion of GLP-1 showed a robust glucose-lowering effect in patients with type 2 diabetes [6]
