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This regulatory system evolved during thousands of years to cope with insufficient energy supply rather than with a need to burn off an excess of calories

Lund-Johansen et al., 1992)

Modulation of non-NMDA glutamate receptor-mediated synaptic transmission is involved in GLP-1-induced effects ( in vitro electrophysiological recordings further demonstrated that exendin-4 elicits an early fast excitatory response dose-dependently ( via increasing neuronal survival in the CA1, CA3, and DG regions of hippocampus ( The olfactory bulb is the basic brain region responsible for olfactory information

By 2025, that number had fallen to 37%

The study tested several dose levels: 1 mg, 4 mg, 8 mg, and 12 mg

2024, doi: 10.5603/cd.102035