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The 0.25 mg starting dose is below the therapeutic threshold its only purpose is to allow your gut to adapt

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Each dose level should normally be used for at least one month
How Hormonal Changes Influence Weight, Sleep, and Daily Function Hormones guide important processes related to metabolism, appetite, temperature regulation, sleep cycles, and emotional patterns

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doi: 10.1371/journal.pone.0058784 [DOI] [PMC free article] [PubMed] [Google Scholar] 210.Cai HY, Hlscher C, Yue XH, et al
