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Abbreviations GLP-1: glucagon-like peptide-1 GLP-1RA: glucagon-like peptide-1R receptor agonists SARS-CoV-2: severe acute respiratory syndrome coronavirus 2 COVID-19: coronavirus disease 2019 ACE2: angiotensin-converting enzyme 2 RAAS: reninangiotensinaldosterone system DPP4: dipeptidyl-peptidase 4 NF-B: nuclear factor kappa-light-chain-enhancer of activated B cells TNF-: tumor necrosis factor alpha IL-1: interleukin 1 beta IL-6: interleukin 6 DM: diabetes mellitus VCAM-1: vascular cell adhesion molecule 1 -SMA: alpha-smooth muscle actin TGF-: transforming growth factor beta Bcl-2: B-cell lymphoma 2 LPS: lipopolysaccharides SGLT2i: sodium-glucose transport protein 2 inhibitor ROS: reactive oxygen species PCR: polymerase chain reaction ANP: atrial natriuretic peptide PKA: protein kinase A PKC: protein kinase C PKB: protein kinase B NAFLD: non-alcoholic fatty liver disease CRP: c-reactive protein IFN-: interferon gamma ARDS: acute respiratory distress syndrome ALI: acute lung injury IPF: Idiopathic pulmonary fibrosis CD4+: cluster of differentiation 4 Caspase: cysteine-dependent aspartate-directed proteases NADPH: nicotinamide adenine dinucleotide phosphate RIPK3: receptor-interacting protein kinase-3 PI3K: phosphatidylinositol-3 kinase PKC : protein kinase C cAMP: cyclic adenosine monophosphate CREB: cAMP response element-binding protein Bcl-xL: B-cell lymphoma-extra large References Papers of special note have been highlighted as either of interest () or of considerable interest () to readers

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Saxenda is only available following consultation with a specialist weight management service and is currently indicated in adults with a BMI of 35+ (or 32.5+ for at-risk ethnicities), non-diabetic high blood sugar and cardiovascular risk factors such as high blood pressure, and high cholesterol

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Additionally, liraglutide, orforglipron, semaglutide, and tirzepatide were associated with increased vomiting risk, while cagrilinitide and exenatide showed no significant increase