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This isn't just another dry, academic walkthrough

Cardio- and reno-protective effects are unlikely to be solely explained by the mechanisms used by these drugs to lower blood glucose levels, as the same effects are not seen with drugs that have stronger antihyperglycaemic actions [111], and were not dependent upon the degree of HbA1c reduction [113,114,115]

Trends Endocrinol Metab 22:2433 Tiano JP, Delghingaro-Augusto V, Le May C et al (2011) Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes

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These are pragmatic upper bounds, not formal equivalence doses

34 Nearly similar pooled proportions of acute pancreatitis, ranging from 0.3% to 0.4%, were reported for all three doses