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The dual agonists also lowered blood sugar and increased insulin secretion in mice, monkeys, and humans

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Because weight loss is rapid, users often lose a significant amount of muscle mass
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Although phentermine is FDA approved for short-term use only, healthcare providers sometimes prescribe it off-label (for non-FDA-approved use) for long-term weight management

2019: Novo Nordisks Rybelsus (a form of semaglutide taken by mouth) is approved for medical use in the U.S
