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That includes proactive management of side effects, candid conversations about the long-term nature of treatment, infrastructure to identify and support patients at risk of stopping and addressing the cost barriers that make GLP-1 therapy unsustainable for many. These measures are especially important, Al-Aly noted, because the cardiovascular protection provided by GLP-1 medication builds slowly, but it erodes quickly

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Clinical trial data showed that 5-6% of participants experienced hair loss at higher doses, compared to about 1% taking placebo

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and the placebo-adjusted mean percent change from baseline to week 24 in body weight were 7.7%, 11.4%, and 12.3% with mazdutide 3 mg, 4.5 mg and 6 mg, respectively
