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Similarly, following studies observed significant clinical improvement in PsO patients with obesity and T2DM, linking improvements to both weight loss and direct immunomodulation (40)

The GLP-1R and GIPR dual agonist enhances insulin secretion, improve glucose tolerance, reduces food intake, and decreases visceral adiposity and body-weight gain in the rodent model of diabetes and obesity

Understanding whether these drugs are physically crossing into the brain or having an effect by some secondary mechanism is important because drugs that cross the blood-brain barrier can be more effective but also introduce safety risks, DiMarchi says

By enhancing the body's natural response to food intake, GLP-1 receptor agonists help control hunger and reduce caloric intake

GLP-1 receptor agonists: A new treatment in Parkinsons disease

Lixisenatide: a review of its use in patients with type 2 diabetes mellitus