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Abstract Obesity has been historically a stubborn chronic metabolic disease, resistant to multiple therapeutic modalities
Its mechanismaffecting appetite, fullness, stomach emptying, and blood sugarexplains associated side effects
If youre taking Ozempic or anything similar, nows a good time to book a check-up
Some compounded formulations address this directly by including B12 in the semaglutide formulation or adding glycine for additional metabolic support
The effects appear to rely on GLP-1Rs located in the NAc shell and lateral septum, supporting the notion of region-specific neuromodulation
Am J Med 2009;122:528-34.ArticlePubMed 243
