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A population-based study from Scandinavia provides some real-world information.

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Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class

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In contrast, pregnancy enhances hormonal crosstalk through placental hormones, triggering metabolic realignments necessary for fetal energy demands