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[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Hamamah S., Amin A., Al-Kassir A.L., Chuang J., Covasa M
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Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1) Diabetes Care

A meta-analysis showed that GLP-1RA and SGLT2 inhibitor combination therapy was associated with a greater reduction in HbA1c (0.74%), body weight (1.61 kg), and systolic blood pressure (3.32 mmHg) than SGLT2 inhibitor monotherapy ( Conclusion and Perspectives GLP-1RAs are widely used in the treatment of T2D

The Endocrine Society's Clinical Practice Guideline on pharmacological management of obesity recommends considering AOMs for patients who experience weight regain after bariatric surgery, particularly when lifestyle modifications prove insufficient

GLP-1 receptor agonists may improve psoriatic skin disease through combined metabolic and immunomodulatory effects Observational studies show reductions in PASI scores, with improvements of approximately 40% to 80% Treatment is associated with better patient-reported quality of life Benefits extend beyond glycemic control and weight loss Agents such as semaglutide and liraglutide reduce inflammatory markers, including C-reactive protein and interleukin-6 Improvements in lipid profile and reductions in visceral fat have been reported Psoriasis improvement may correlate with reduced superficial adiposity and decreased dermal T-cell density GLP-1 receptor agonists can be safely combined with methotrexate, cyclosporine, and biologic therapies The safety profile is generally favorable, with mostly transient gastrointestinal side effects Serious adverse events such as pancreatitis and gallbladder complications are rare but require monitoring MSc