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Adverse reactions in patients 10 to 17 years of age treated with BYDUREON (exenatide extended-release) were similar to that in adults DRUG INTERACTIONS Oral Medications BYDUREON BCise slows gastric emptying and may reduce the rate of absorption of orally administered drugs Warfarin Increased international normalized ratio (INR) sometimes associated with bleeding has been reported with concomitant use of exenatide with warfarin

In addition, rodent studies demonstrating thyroid C-cell hyperplasia and tumors led to class warnings and contraindications in susceptible populations

A small trial including 8 patients with T1D showed improved postprandial hyperglycemia despite 20% insulin dose reduction (69)

Results were expressed as the mean SEM

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