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26 GLP1 binds to and mediates the biological activation through the G proteincoupled receptor GLP1R

Nonetheless, the TMD conformation differed and, overall, the receptor was relatively stable, exhibiting less flexibility compared with GLP-1R bound to exendin-4 or oxyntomodulin (Supplementary Fig

10.2337/dc18-2584 Diabetes Care 93 ZhaoL.LiZ.VongJ.ChenX.LaiH.YanL.et al (2020)