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Keywords: glucagon-like peptide-1 receptor agonists, substance-related disorders, braingut axis, alcoholism, tobacco use disorder, cocaine-related disorders, amphetamine-related disorders, opioid-related disorders, bloodbrain barrier, translational research, biomedical 1

Ann Surg 276(5):e417e424 Goldberg I, Nie L, Yang J, Docimo S, Obici S, Talamini M et al (2021) Impact of bariatric surgery on the development of diabetic microvascular and macrovascular complications

Results show broad benefits with a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimers disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions

Hypothalamic ghrelin suppresses pulsatile secretion of luteinizing hormone via -endorphin in ovariectomized rats

Endotoxin contamination triggers inflammatory responses

Concerns have been raised that the rate of DKA in real-world practice would surpass rates seen in closely supervised RCTs [37]