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For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting

Dosing Errors and Medical Emergencies The Food and Drug Administration (FDA) estimates that 10 deaths and 100 hospitalizations may be connected to compounded GLP-1 dosing errors

doi: 10.1210/clinem/dgab578

They increase anti-inflammatory IL-10 levels in the heart 9

Pain intensity is typically mild to moderate and worsens with head movement, especially when bending forward or lying down

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