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In conclusion, some animal studies have provided evidence that the use of GLP-1 receptor agonists increases the risk of thyroid disease, but this evidence has not been confirmed in humans

Historically, this increased insulin response mediated by GLP-1 and GIP had been attributed to factors termed incretins (derived from incretion, a term used at that time to refer to a secretion that remains inside the body), hence the name incretin effect is still used today to describe the rise in insulin mediated by the action of these hormones

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What Is Retatrutide and How Does It Work Retatrutide is often described as a tri-agonist

This is because doctors are still doing clinical trials on the drug