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What the clinical trial evidence shows Mounjaro (tirzepatide) ~22.5% average body weight lost at 72 weeks ( SURMOUNT-1, 15mg) Wegovy (semaglutide) ~14.9% average body weight lost at 68 weeks ( STEP-1 , 2.4mg) Saxenda / Nevolat (liraglutide) ~5-8% average body weight lost at 56 weeks ( SCALE trial ) For context, prior to GLP-1 medications, the most effective non-surgical weight loss intervention available was a combination of intensive lifestyle modification and Orlistat , which typically produces 5 to 8% weight loss

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David: Well, I just want us to kind of agree that we shouldnt look back with judgmental eyes, OK

An alternative approach aiming to maximize the efficacy of GLP-1 involves the delivery of nuclear receptor agonists to specific tissues characterized by the expression of GLP-1R

If there has been a prolonged interruption of several weeks, your clinician may recommend restarting at a lower dose initially to minimise gastrointestinal side effects such as nausea, though this is based on clinical judgement rather than specific product guidance

Urinary tract infections in patients with diabetes treated with dapagliflozin