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In TRIUMPH-1, the first large Phase 3 trial (a large human trial with thousands of participants) in adults with obesity, retatrutide produced an average weight loss of 28.3% at the 12 mg dose after 80 weeks

Study participants will be randomly assigned to two groups: one receiving the study drug and the other receiving a placebo

The full, honest, sometimes messy reality of what happens when men start tirzepatide, what the timeline looks like week by week, and how to optimize every phase of the process for the best possible outcome

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Abdominal Pain : Some users report abdominal pain or discomfort

However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug