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Limited preclinical and clinical data, particularly from MRI-based studies, suggest that skeletal muscle changes induced by GLP-1RAs may be adaptive

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That mechanistic understanding is arguably the most valuable scientific output from this line of research

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Semaglutide is also suggested to indirectly inhabit the activity of neuropeptide Y/Agouti-related peptide (NPY/AgRP) contributing to its neuroprotective profile [57,58]