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When fiber reaches the colon, beneficial gut bacteria ferment it into short-chain fatty acids (SCFAs), which stimulate the release of GLP-1

A UCLA study published in ACR Open Rheumatology found that GLP-1 receptor agonists such as semaglutide and tirzepatide may reduce rheumatoid arthritis activity and cardiovascular risk factors in people with obesity, suggesting potential dual benefits for metabolic and inflammatory health.