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These molecules would enhance receptor signaling when the endogenous ligand is present, thereby providing an opportunity to enhance the normal GLP-1 response selectively [64] Some of these PAMS interact with the less active form of GLP-1, potentiating the activity of GLP-1(936) by interacting with both the peptide and the receptor [64,65,66]

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Most clinical trials and studies do not list hot flashes as a significant side effect

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& Murphy, C

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