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We demonstrate that the therapeutic potential of GLP-1RAs in RA is mediated by their dual targeting of two key pathological pathways: suppressing a previously unidentified cGAS-STING-ferroptosis axis in chondrocytes and reprogramming synovial macrophages toward an M2 reparative phenotype, which collectively helps maintain joint homeostasis

VW performed the statistical analysis
PlexusDx works with prescribing providers to ensure your complete medication history is reviewed before initiating any GLP-1 protocol

Obesity segment accounted for USD 10.52 Billion in 2025, representing 28% share of the GLP-1 Drug Market, and is expected to grow at a CAGR of 29.4% driven by increasing obesity prevalence and rising awareness of weight management therapies

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Lamont B.J., Li Y., Kwan E., Brown T.J., Gaisano H., Drucker D.J