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GLP-1R works through the combination of the endogenous ligand Glucagon-like peptide-1 (GLP-1) or exogenous agonists, which activate multiple intracellular signaling pathways that enhance insulin secretion, inhibit glucagon secretion, protect -cells from apoptosis, delay gastric emptying and increase satiety

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Begin each session with a 5-10 minute warm-up consisting of light cardiovascular activity (like walking or cycling) and dynamic stretches to increase blood flow and muscle temperature

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If interventions are not started, the increased demand for insulin can overload pancreatic -cells leading to pancreatic -cell failure, decreased insulin secretion, and uncontrolled glycemia (Figure 1)