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It is contraindicated for use in patients with a personal or family history of medullary thyroid carcinoma and in those with multiple endocrine neoplasia type 2

Patients with multiple high-risk variants often see better long-term outcomes with extended GLP-1 use, while those with fewer genetic risk factors may achieve durable results with temporary treatment plus lifestyle modification

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Other common effects include constipation, decreased appetite, and occasional vomitingmost patients experience minimal symptoms or adjust well during the gradual dose escalation phase

Semaglutide can also improve HF outcomes by impacting the pathophysiology of HF with preserved ejection fraction (HFpEF) patients based on three new substudies from the STEP-HFpEF program