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doi: 10.1016/j.yhbeh.2019.104640 243 GejlMGjeddeAEgefjordLMollerAHansenSBVangKet al

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these factors may contribute to a higher incidence of hepatobiliary adverse events [2,37]

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Adverse effects were mostly mild gastrointestinal symptoms

The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)