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In the HARMONY-2 (efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide) clinical study, patients were randomized to receive either once-weekly albiglutide (30 mg, titrated up to 50 mg if required for glycemic control) or 10 units of insulin glargine once daily

Nuclear factor kappa B (NF-B), NH2-terminal Jun kinases, and p53 MAPK are transcriptionally regulated pathways that have been considered one of the most important stress-signaling pathways, and oxidative stress plays a role in the development of type 2 diabetes mellitus through their involvement (14)

Thats one of the reasons some people prefer newer GLP-1 medications like semaglutide (Ozempic and Wegovy) or tirzepatide (Mounjaro and Zepbound), which only require one weekly injection

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The full report contains the complete reference list and detailed citations

[DOI] [PubMed] [Google Scholar] 64.Astrup A., Rossner S., Van Gaal L., Rissanen A., Niskanen L., Al Hakim M