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In a 10-week, once-daily, multiple-dose trial, 84 healthy males received 20 or 40 mg oral semaglutide (with 300 mg SNAC), placebo, or placebo with SNAC, and 23 males with type 2 diabetes (T2D) received 40 mg oral semaglutide (with 300 mg SNAC), placebo, or placebo with SNAC

It enhances glucose-dependent insulin secretion, suppresses glucagon, and slows gastric emptying key mechanisms for glucose control

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Semaglutide is a long-acting glucagon-like peptide 1 (GLP-1) agonist, while tirzepatide is both a GLP-1 agonist and a glucose dependent insulinotropic polypeptide (GIP)

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Janumet XR is an oral extended-release tablet that combines sitagliptin and metformin hydrochloride for adults with type 2 diabetes when used with diet and exercise