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As anticipated, patient preference is towards GLP-1 RA profiles associated with less frequent dosing, with once-weekly preferred to once-daily, with the latter preferred over twice-daily [123,124,125]

UK Medical Guide Weight loss injections, particularly glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda), can cause dizziness in some individuals

doi: 10.1038/nn1214

But needles remain one of the most cited barriers to starting treatment

In the SURMOUNT-5 trial, tirzepatide (Zepbound) resulted in significantly greater weight loss than semaglutide (Wegovy) in adults with obesity and no history of diabetes

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