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Acute pancreatitis, gallbladder events, thyroid C-cell concerns (a rat-derived signal that has never been confirmed in humans), and diabetic retinopathy progression in patients with existing retinopathy

The activation of the area postrema during the peak levels of GLP-1 RAs may provide an explanation for gastrointestinal symptoms

doi: 10.2337/dci18-0018

By comparison, a group of people who also dieted and exercised, but then received dummy shots, lost weight initially but then regained some, researchers reported in the journal Nature Medicine

If you experience any suspected side effects from a product whether a licensed medicine or an unlicensed supplement you can report this to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk

The STEP trials showed average weight loss of 5 percent by 4 weeks and 15 percent by 68 weeks, though individual timelines vary based on genetics and adherence