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Hypoxic conditions can also lead to a phenomenon known as DPP-4 shedding whereby transmembrane DPP-4 is cleaved from the membrane and released into the circulation in a soluble form

These setbacks demonstrate that while GLP-1 RAs show promising biomarker effects in the brain, translating them into meaningful clinical outcomes in neurodegeneration remains an unresolved challenge

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But what are semaglutide (GLP-1 RA) drugs, and how do they work

However, GLP-1 RAs significantly increased the change in the 6-min walk test (MWT) distance (MD: 19.74, p = 0.002)