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Metformin has also been associated with undesired side-effects, as gastrointestinal distress, and has modest effects on body weight in women with PCOS and obesity 25

TEXT ON-SCREEN: You should change (rotate) your injection site with each injection

John Aurora , PharmD, endocrinology clinical pharmacy specialist at Tufts Medical Center in Boston Hanna Lee , MD, endocrinologist at Lenox Hill Hospital in New York City Our health content is for informational purposes only and is not intended as professional medical advice

Individuals engaging in unstructured reduced dietary intake while on GLP-1 RAs should be monitored for gut microbiome diversity, as preserved diversity is critical for maintaining the anti-inflammatory effects associated with a healthy microbiome

If youre not responding, your provider adjusts your protocol or youre covered by the 60-day guarantee

This is particularly relevant given the intersection of estrogen signaling, GLP-1 pathways, and genetic risk factors related to APOE4 status