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Higher doses (7.5 mg and 15 mg) are associated with higher nausea rates in clinical trials, but individual responses vary widely based on genetics, stomach sensitivity, and food timing

Mean body weight at randomization (Week 20) was 96.1 kg and mean BMI at randomization (Week 20) was 34.4 kg/m2

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The best designed study to date is a systematic review of 80 randomized clinical trials involving 107,860 participants, which found no association with GLP-1RA treatment and serious psychiatric adverse effects: major depression, suicide, or psychosis (105)