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The term has emerged in informal community discussion as a shorthand for "the third generation of GLP-class peptides" specifically retatrutide, which acts on three receptors (GLP-1, GIP, and glucagon)

Biomedicines 10 , 116 (2022)

The evidence base is significant

At our practice, we ensure that any off-label use of Ozempic for weight loss is carefully considered and monitored under the guidance of our experienced healthcare providers

The company offers compounded versions of both, and the prescribing clinician determines which medication is appropriate based on individual health evaluation