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Keywords: obesity, leptin resistance, partial leptin reduction, weight loss, treatment strategies Introduction The prevalence of obesity and associated diseases has been obviously increasing in recent years, and there are growing interests in the pathogenesis of obesity and the development of anti-obesity drugs

Adequate protein intake is particularly critical because rapid weight loss can lead to significant muscle loss alongside fat loss

Patients should rotate injection sites with each weekly dose

Talking to a healthcare provider about assessing hormone levels is a good place to begin the weight management journey

Key Takeaways Retatrutide is investigational and does not have an approved weight-loss dose

In a phase II trial, nondiabetic individuals with obesity shed 24.2% of their body weight on average after 48 weeks