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The SELECT trial, which included patients with CV disease and overweight or obesity (many also had increased risk for diabetes), showed a reduction in major adverse CV events (defined as CV death, nonfatal heart attack, and nonfatal stroke) of 20% with weekly subcutaneous semaglutide 2.4 mg
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GLP-1 agonists may lessen alcohol, smoking and possibly drug addictions
The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter
doi: 10.3389/fendo.2024.1330936 [DOI] [PMC free article] [PubMed] [Google Scholar] 32
