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These patients may benefit from a slower titration (holding at an intermediate dose for 8 weeks instead of 4) or a reduced maintenance dose of 1.7 mg, which is permitted under the FDA label [4]

Although hepatic steatosis was once considered a benign condition, accumulating evidence now demonstrates that MAFLD is a progressive disease with potential to evolve into advanced liver fibrosis, cirrhosis, and HCC (13, 15)

[3] In various cellular processes, NAD+-dependent/-consuming enzymes modify proteins post-translationally using NAD+ and its other forms as substrates

10.3389/fphar.2022.817662 [DOI] [PMC free article] [PubMed] [Google Scholar] 16.Ali Z, Ismail M, Khan F, Sajid H

We see a higher incidence of osteoporosis