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Biochemical Mechanisms: How Semaglutide and Tirzepatide Differ at the Molecular Level Semaglutide is a synthetic GLP-1 receptor agonist sharing 94% sequence homology with endogenous human GLP-1 (glucagon-like peptide-1)

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For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses