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The main molecular mechanisms of GLP-1RA in obesity reduction include the increased production of insulin by the cAMP/PKA pathway in pancreatic -cells, along with an augmented translocation of GLUT-4 in the cellular membrane for improved glucose homeostasis, and energy expenditure by lipolytic cycle stimulation
Risk of diabetic retinopathy and diabetic macular oedema with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database
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Five BMI subgroups were assessed: less than 25 kg/m 2 , 25 kg/m 2 to 29.9 kg/m 2 , 30 kg/m 2 to 34.9 kg/m 2 , 35 kg/m 2 to 39.9 kg/m 2 and 40 kg/m 2 or higher
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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Sorli C, Harashima S-I, Tsoukas GM, et al
