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Silencing the Insr gene in primary brain microvascular endothelial cells (BMECs) The sequences of the siRNA-Insr used were as follows: 5-GCACAGACCAUUUGAGAAATT-3 (sense) and 5-UUUCUCAAAUGGUCUGUGCTT-3 (antisense)

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Comparative Analysis : Research comparing SGLT2 inhibitors (another class of diabetes medications) to GLP-1 agonists found that SGLT2 inhibitors might reduce the incidence of gout, possibly due to their effects on uric acid levels
Other barriers include nausea, constipation, or appetite suppression so strong that patients struggle to eat enough protein
