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It should be noted that Figure 2 is a simplified representation of the overall approach recommended by the ADA/EASD and includes only recommendations up to the point of dual antihyperglycemic therapy

Because doses are lower, patients dont experience the severe appetite suppression that can unintentionally lead to muscle loss

Third, residual confounding from unmeasured factors such as smoking status, alcohol intake, family history of cancer, and dietary patterns may have influenced the observed associations but could not be adjusted for in this aggregate-level analysis

doi: 10.3390/antiox10081175 [DOI] [PMC free article] [PubMed] [Google Scholar] 29

Diabetes 64 , 25372549 (2015)

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