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& Foulkes, W

It increases heart rate and blood pressure, which limits its use in patients with hypertension or cardiovascular disease

doi:10.3390/cimb46120872

The incretin effect was estimated to account for approximately 50% - 70% of the postprandial insulin responses in healthy individuals and may be substantially reduced to 20% 30% in individuals with type 2 diabetes mellitus (T2DM) (6, 7), a complex disorder arising from inadequate compensation of insulin secretion by pancreas to counter peripheral insulin resistance

[DOI] [PubMed] [Google Scholar] Nyberg J, Anderson MF, Meister B, Alborn AM, Strm AK, Brederlau A, Illerskog AC, Nilsson O, Kieffer TJ, Hietala MA, et al

However, substantial and sustained cholesterol improvements typically require 5% or greater body weight reduction