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PMID: 22182839
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Additionally, GLP-1RAs have beneficial effects on cardiovascular risk factors, such as blood pressure and lipid levels

FDA Drug Safety Communication , FDA Warns That DPP4 Inhibitors for Type 2 Diabetes May Cause Severe Joint Pain accessed July 26, 2023, 166

10.1056/NEJMoa1607141 8

The synergistic effect addresses appetite through a dopamine-reward and POMC-activation pathway rather than GLP-1 receptor signaling

Their efficacy though, both in terms of inhibiting plasma DPP-4 activity and as antidiabetic agents, appears to be similar [44]
