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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Qualls JE, Kaplan AM, van Rooijen N, Cohen DA

These effects are mediated centrally (427) Glycemic Efficacy In a review of three randomized trials in patients with T2DM comparing pramlintide vs

If metformin at a maximum tolerated dose does not achieve the HbA1c target after 3 months, add a second oral agent (a sulfonylurea [SU], thiazolidinedione [TZD], dipeptidyl peptidase 4 [DPP-4] inhibitor, or sodium-glucose cotransporter-2 [SGLT2] inhibitor), a glucagon-like peptide-1 (GLP-1) receptor agonist, or a basal insulin ( TABLE 2 )

On weight loss, there is not

Other factors influencing GLP-1 secretion include activation of the olfactory receptor OR51E1 using nonanoic acid, which stimulates secretion of GLP-1 and PYY in human and rodent enteroendocrine L-cells [345]

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