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How Does the Triple Agonist Mechanism Work

The AMPLITUDE-O trial, which included more high-risk patients and had a higher prevalence of kidney disease than the previous GLP-1RA CVOT trials, observed an overall lower incidence of at least one MACE composite event
The net effect of potential receptor activation in the context of other metabolic changes is unclear and requires further investigation

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While you might experience low sex drive due to being in a caloric deficit, it is not a direct causation of GLP-1
