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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1

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Such improvements are crucial in mitigating the risk of obesity-related comorbidities, notably cardiovascular diseases and type 2 diabetes, which stand as leading contributors to global morbidity and mortality