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Role of ovarian hormones in the long-term control of glucose homeostasis

Binding of GLP-1 to GLP1R has multiple effects, including enhancing insulin secretion from pancreatic beta cells in response to glucose, increasing insulin expression, preventing beta-cell apoptosis, promoting the formation of new beta cells, reducing glucagon secretion, slowing down stomach emptying, promoting satiety, and improving glucose disposal in peripheral tissues

Food and Drug Administration (FDA) and European Medicines Agency (EMA) submissions

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Mounjaro is also a GLP-1 RA but slightly different in that it targets both GLP-1 (glucagon like peptide) and another hormone, GIP (glucagon dependent insulinotropic polypeptide)

The IPGTTs were performed (glucose 2 g kg 1 i.p.) 5 min, 30 min, 2 h or 4 h after dosing and blood glucose was measured at different time points after the glucose challenge