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The ability of probenecid to inhibit cAMP accumulation in GLP-1(2836)treated human caECs further supports our finding that GLP-1(2836) works through sAC to increase intracellular cAMP levels (Supplemental Figure 8C)
H., Lingvay, I., Deanfield, J., et al
(2020) Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
These efforts underscore the potential of GLP-1RAs to offer novel treatment options and improve patient outcomes across a range of inflammatory diseases.
L., Nguyen, Q
10.1056/NEJMoa1411892
