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There is no single "best" answer, as the right medication for you depends on a variety of personal factors

Additional but rare side effects include: low blood sugar (hypoglycemia) feeling cold unusual muscle pain dizziness slow or irregular heart rate trouble breathing metallic taste changes to nails on fingers and toes Low b12 levels DRUG INTERACTIONS As with other medications, metformin can interact with alcohol and certain medications, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, corticosteroids, hormone replacement therapy and estrogens, oral contraceptives, carbonic anhydrase inhibitors, nifedipine, thiazides or furosemide and other diuretics, phenothiazines, phenytoin, nicotinic acid (niacin), multidrug and toxin extrusion inhibitors, sympathomimetics, calcium channel blockers, isoniazid (antibiotic for tuberculosis), insulin and glyburide or other medications for diabetes, and medications for thyroid disease

Obese mice were treated with semaglutide or a GLP-1/glucagon dual agonist (survodutide) and then had one limb immobilized with a cast for 7 days

The total cost will also vary by pharmacy and location

doi: 10.1016/j.jhepr.2019.07.002 138 PatelVJoharapurkarAKshirsagarSSutariyaBPatelMPatelHet al

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